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Scientist

Jan Spacek

Education

  • BS in Molecular Biology and Genetics, Masaryk University, Czech Republic (2009)
  • MS in Molecular Biology and Genetics, Masaryk University, Czech Republic (2011)
  • PhD in Genomics and Proteomics, Masaryk University, Czech Republic (2018)

Research summary

My research focus is currently shifting from analytical bioelectrochemistry and development and optimization of COVID 19 diagnostics towards astrobiology.

Current projects include:

  • Study of organic compounds reactions in concentrated sulfuric acid under conditions simulating Venusian cloud aerosols.
  • Development of Agnostic Life Finder (ALF) instrument that can be used for search for life on Mars.
  • Optimization and development of COVID-19 tests.
  • Analytical electrochemistry of natural and unnatural nucleic acids.

Recent Publications

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Agnostic Life Finder (ALF) for Large-Scale Screening of Martian Life During In Situ Refueling
Spacek, J. & Benner, S.A.
Astrobiology (2022) 22, 8, DOI:10.1089/ast.2021.0070
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A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concern
Nguyen, L. T., Macaluso, N. C., Pizzano, B. L., Cash, M. N., Spacek, J., Karasek, Jain, P. K., et. al.
EBioMedicine , Lancet (2022) 77, 103926. DOI:10.1016/j.ebiom.2022.103926

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A simple electroanalysis of polyG RNA in mixtures with 3', 5'-cyclic guanosine monophosphate achieved by selective desorption of the monomers from the electrode surface
Hesko, O., Fojta, M., & Spacek, J.
J. Electroanal. Chem , Elsevier (2021) 901, 115773. DOI: 10.1016/j.jelechem.2021.115773
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The Limits to Organic Life in the Solar System: From Cold Titan to Hot Venus
Benner, S. A., & Spacek, J.
LPI Contributions , LPI (2021) 2629, 4003.
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Chemical guidance in the search for past and extant life on Mars. Decadal Survey in Planetary Sciences and Astrobiology
Benner, S. A., Biondi, E., Kim, H.-J., Spacek, J.
Bulletin of the AAS , AAS (2020) 53(4), DOI:10.3847/25c2cfeb.266df7e7
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Electrochemical Reduction and Oxidation of Eight Unnatural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode
Spacek, J., Karalkar, N., Fojta, M., Wang, J., Benner, S. A
Electrochimica acta , International Society of Electrochemistry (2020) 362:137210, DOI:10.1016/j.electacta.2020.137210
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Electroanalysis of unnatural base pair content in plasmid DNA generated in a semi-synthetic organism
Spacek, J., & Fojta, M.
Electrochimica acta , International Society of Electrochemistry (2020) 364, 137298. DOI: 10.1016/j.electacta.2020.137298
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Electrochemical Reduction and Oxidation of Six Natural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode in the Presence or Absence of Ambient Oxygen
Spacek, J., Fojta, M., & Wang, J.
Electroanalysis , Wiley (2019) 31(10), 2057-2066. DOI: 10.1002/elan.201900417
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Butylacrylate-nucleobase Conjugates as Targets for Two-step Redox Labeling of DNA with an Osmium Tetroxide Complex
Havranova-VidlakovA, P., Spacek, J., Vítova, L., Hermanova, M., Dadova, J., Raindlova, V., Havran, L., et al.
Electroanalysis , Wiley (2018) 30(2), 371-377. DOI: 10.1002/elan.201700702
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Label-free detection of canonical DNA bases, uracil and 5-methylcytosine in DNA oligonucleotides using linear sweep voltammetry at a pyrolytic graphite electrode
Spacek, J., Danhel, A., Hason, S., & Fojta, M.
Electrochem. commun. , Elsevier (2017) 82, 34-38. DOI: 10.1016/j.elecom.2017.07.013
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