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Nigel Richards's Publications

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The chemistry of formycin biosynthesis
Richards NGJ, Naismith JN
Front. Chem. Biol., Frontiers Media SA (2024) 11 July: 3, 1428646. DOI: 10.3389/fchbi.2024.1428646
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Arginine kinase activates arginine for phosphorylation by pyramidalization and polarization
Falcioni F, Molt RW Jr., Jin Y, Waltho JP, Hay S, Richards, NGJ, Blackburn GM
ACS Catal, ACS (2024) 16 April: 14(9), 6650-6658. DOI: 10.1021/acscatal.4c00380
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Reactivity and mechanism in chemical and synthetic biology
Richards, NGJ, Bearne SL, Goto Y, Parker EJ
Phil. Trans. R. Soc. B Biol. Sci., The Royal Society Publishing (2023) 27 February: 378(1871), 20220023. DOI: 10.1098/rstb.2022.0023
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Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase
Li W, Girt GC, Radadiya A, Stewart JJP, Richards NGJ, Naismith JN
Open Biology, The Royal Society Publishing (2023) 11 January: 13(1), 220287. DOI: 10.1098/rsob.220287
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Development of triazole-conjugated dihydropyrimidinone (DHPM) derivatives as potential P-glycoprotein inhibitors
Bijani S, Shaikh F, Mirza D, Siu SWI, Jain N, Ferreira RJ, dos Santos DJVA, Rawal R, Richards NGJ, Shah A, Radadiya A
ACS Omega, ACS (2022) 17 May: 7(19), 16278-16287. DOI: 10.1021/acsomega.1c05839
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Functional characterization of two PLP-dependent enzymes involved in capsular polysaccharide biosynthesis from Campylobacter jejuni
Riegert AS, Narindoshvili T, Coricello A, Richards NGJ, Raushel FM
Biochemistry, ACS (2021) 21 September: 60(19), 2836-2843. DOI: 10.1021/acs.biochem.1c00439
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Building better polymerases: Engineering the replication of expanded genetic alphabets
Ouaray, Z., Benner, S. A., Georgiadis, M. M., Richards, N. G. J.
J. Biol. Chem., ASBMB (2020) 11 December: 295(50):17046-17059, DOI:10.1074/jbc.REV120.013745
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Improving the treatment of acute lymphoblastic leukemia
Radadiya A, Zhu W, Coricello A, Alcaro S, Richards NGJ
Biochemistry, ACS (2020) 8 September: 59(35), 3193-3200. DOI: 10.1021/acs.biochem.0c00354
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Uncovering the chemistry of C-C bond formation in C-nucleoside biosynthesis: Crystal structure of a C-glycoside synthase/PRPP complex
Gao S, Radadiya A, Li W, Liu H, Zhu W, de Crecy-Lagard V, Richards NGJ, Naismith JN
Chem. Comm., Royal Society of Chemistry (2020) 14 July: 56(55), 7617-7620. DOI: 10.1039/d0cc02834g
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Tautomeric equilibria of nucleobases in the hachimoji expanded genetic alphabet
Eberlein, L., Beierlein, F.R., van Eikema Hommes, N.J.R., Radadiya, A., Heil, J., Benner, S.A., Clark, T., Kast, S.M., and Richards, N.G.J.
J. Chem. Theory Comput., ACS (2020) 14 Apr: 16(4):2766-2777, DOI:10.1021/acs.jctc.9b01079
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Whole-genome sequence of Streptomyces kaniharaensis Shomura and Niida SF-557
Zhu W, Liu X, Hughes M, de Crecy-Lagard V, Richards NGJ
Microbiol. Resource Announ., ASM (2020) Apr: 9(14), e01434. DOI: 10.1128/MRA.01434-19
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Building better enzymes: Molecular basis of improved non-natural nucleobase incorporation by an evolved DNA polymerase
Ouaray Z, Singh I, Georgiadis MM, Richards NGJ
Protein Sci., The Protein Society (2020) Feb: 29(2), 455-468. DOI: 10.1002/pro.3762
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