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Senior Fellow

Catherine Schein

Education

  • BA in Biochemistry. University of Pennsylvania
  • M.S. in Biochemical Engineering. Massachusetts Institute of Technology (MIT)
  • Ph.D. in Technical Microbiology. Swiss Federal Institute of Technology (ETH)
  • Postdoc in Molecular Biology. Molecular Biology Institute I, University of Zürich (Supported by Biogen, SA)

Research Sumamry

Dr. Schein became a senior fellow at FfAME in 2013. She is working together with our experts in polymerases to design and select novel inhibitors of human enteroviruses. Dr. Schein began her career in research and development at Biogen, producing interferons for early clinical studies. She later became an Oberassistentin at the Swiss Federal Institute of Technology in Zurich (ETHZ) and was an Associate Professor at the University of Texas Medical Branch (UTMB) at Galveston until 2012. Her major projects have ranged from studying the interaction of interferons with ribonucleases to designing drugs against microbial pathogens. Her group at the UTMB identified novel inhibitors of anthrax edema factor, using computational compound selection and docking. She also developed and validated a novel method for extracting data from large biological sequence collections, based on determining physicochemical property (PCP) consensus sequences. The method has proved very useful for vaccine design, for example against Dengue virus, and to identify common properties of allergenic proteins. All of these tools are now in use in her current projects. Dr. Schein is a well cited author with over a hundred publications in journals and books.

Dr. Schein recently spoke at the HESI PATC & IFBiC Biotechnology Update Symposium 2013. Click here to view her presentation.
 

A list of recent publications are listed below. For a more complete list, please visit Dr. Schein's Google Scholar Page.

Recent Publications

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Allosteric inhibitors of Coxsackie virus A24 RNA polymerase
CH Schein, D Rowold, KH Choi
Bioorg. Med. Chem. (2016) Volume 24, Issue 4, 15 February 2016, Pages 570-577

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Cross-Reactivity Among Peanut and Tree Nut Allergens
SJ Maleki, H Cheng, JC Wolf, SS Teuber, C Schein, CC Grimm
J Allergy Clin Immunol , American Academy of Allergy, Asthma & Immunology (2016) 137 (2), AB237

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Sequence specificity for uridylylation of the viral peptide linked to the genome (VPg) of enteroviruses
Catherine H Schein, Mengyi Ye, Aniko V Paul, M Steven Oberste, Nora Chapman, Dmitri V Filippov, Kyung Choi
Virology , Elsevier (2015) 484:80-85

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Inositol hexakisphosphate analogs and uses thereof
TC Savidge, P Urvil, D Nauduri, N Oezguen, C Schein, W Braun
US Patent , United States Patent Office (2015) Patent No. 9,200,015

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Membrane Interaction and Functional Plasticity of Inositol Polyphosphate 5-Phosphatases
Werner Braun and Catherine H. Schein
Structure (2014) http://dx.doi.org/10.1016/j.str.2014.04.008

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Assessment of 3D models for allergen research
Power, T.D, Ivanciuc, O., Schein, C.H. and Braun, W.
Proteins: Struct., Funct., Bioinf. , Wiley (2013) 81 (4):545-554

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A general synthetic method toward uridylylated picornavirus VPg proteins
Heden van Noort, G.J., Schein, C.H., Overkleeft, H.S., Marel, G.A., Filippov, D.V.
J. Pept. Sci. , Wiley (2013) 19 (6):333-336

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Structure-Based Redesign of an Edema Toxin Inhibitor
Chen, D, Ma, L., Kanalas, J.J., Gao, J, Pawlik J, Estrella-Jimenez, JE, Walter M.A., Peterson, JW, Gilbertson S.R. and Schein C.H.
Bioorg. Med. Chem. (2012) 20, 368-376 PMCID: PMC3251925

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Simplifying complex sequence information: a PCP-consensus protein binds antibodies against all four Dengue serotypes
Bowen, D.M., Lewis, J.A., Lu, W. and Schein, C.H.
Vaccine , Elsevier (2012) 30(42), 6081-6087

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Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals
Schein, C.H., Bowen, D.M., Lewis, J.A., Choi, K., Paul, A., van der Heden van Noort, G.J., Lu, W. and Filippov, D.V.
BMC Bioinformatics (2012) 13(Suppl 13):S9.

(View publication page for Catherine Schein)

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