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Our Foundation
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Senior Fellow
Catherine Schein
Education
- BA in Biochemistry. University of Pennsylvania
- M.S. in Biochemical Engineering. Massachusetts Institute of Technology (MIT)
- Ph.D. in Technical Microbiology. Swiss Federal Institute of Technology (ETH)
- Postdoc in Molecular Biology. Molecular Biology Institute I, University of Zürich (Supported by Biogen, SA)
Research Sumamry
Dr. Schein became a senior fellow at FfAME in 2013. She is working
together with our experts in polymerases to design and select novel
inhibitors of human enteroviruses. Dr. Schein began her career in research
and development at Biogen, producing interferons for early clinical
studies. She later became an Oberassistentin at the Swiss Federal
Institute of Technology in Zurich (ETHZ) and was an Associate Professor at
the University of Texas Medical Branch (UTMB) at Galveston until 2012. Her
major projects have ranged from studying the interaction of interferons
with ribonucleases to designing drugs against microbial pathogens. Her
group at the UTMB identified novel inhibitors of anthrax edema factor,
using computational compound selection and docking. She also developed
and validated a novel method for extracting data from large biological
sequence collections, based on determining physicochemical property (PCP)
consensus sequences. The method has proved very useful for vaccine design,
for example against Dengue virus, and to identify common properties of
allergenic proteins. All of these tools are now in use in her current
projects. Dr. Schein is a well cited author with over a hundred
publications in journals and books.
Dr. Schein recently spoke at the HESI PATC & IFBiC Biotechnology Update Symposium 2013. Click here to view her presentation.
A list of recent publications are listed below. For a more complete list, please visit Dr. Schein's Google Scholar Page.
Recent Publications
Allosteric inhibitors of Coxsackie virus A24 RNA polymerase
CH Schein, D Rowold, KH Choi
Bioorg. Med. Chem.
(2016) Volume 24, Issue 4, 15 February 2016, Pages 570-577
Cross-Reactivity Among Peanut and Tree Nut Allergens
SJ Maleki, H Cheng, JC Wolf, SS Teuber, C Schein, CC Grimm
J Allergy Clin Immunol
, American Academy of Allergy, Asthma & Immunology (2016) 137 (2), AB237
Sequence specificity for uridylylation of the viral peptide linked to the
genome (VPg) of enteroviruses
Catherine H Schein, Mengyi Ye, Aniko V Paul, M Steven Oberste, Nora Chapman, Dmitri V Filippov, Kyung Choi
Virology
, Elsevier (2015) 484:80-85
Inositol hexakisphosphate analogs and uses thereof
TC Savidge, P Urvil, D Nauduri, N Oezguen, C Schein, W Braun
US Patent
, United States Patent Office (2015) Patent No. 9,200,015
Assessment of 3D models for allergen research
Power, T.D, Ivanciuc, O., Schein, C.H. and Braun, W.
Proteins: Struct., Funct., Bioinf.
, Wiley (2013) 81 (4):545-554
A general synthetic method toward uridylylated picornavirus VPg proteins
Heden van Noort, G.J., Schein, C.H., Overkleeft, H.S., Marel, G.A., Filippov, D.V.
J. Pept. Sci.
, Wiley (2013) 19 (6):333-336
Structure-Based Redesign of an Edema Toxin Inhibitor
Chen, D, Ma, L., Kanalas, J.J., Gao, J, Pawlik J, Estrella-Jimenez, JE, Walter M.A., Peterson, JW, Gilbertson S.R. and Schein C.H.
Bioorg. Med. Chem.
(2012) 20, 368-376 PMCID: PMC3251925
Simplifying complex sequence information: a PCP-consensus protein binds antibodies
against all four Dengue serotypes
Bowen, D.M., Lewis, J.A., Lu, W. and Schein, C.H.
Vaccine
, Elsevier (2012) 30(42), 6081-6087
Physicochemical
property consensus sequences for functional analysis, design of
multivalent antigens and targeted antivirals
Schein, C.H., Bowen, D.M., Lewis, J.A., Choi, K., Paul, A., van der Heden van Noort, G.J., Lu, W. and Filippov, D.V.
BMC Bioinformatics
(2012) 13(Suppl 13):S9.
(View publication page for Catherine Schein)
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- Structure-based design of vaccines, antiviral and antibacterial drugs
- Comparing the physicochemical properties of allergenic proteins and their
epitopes
- Computer modeling of immune system complexes and allergy inducing proteins
- Designing therapeutics against enteric and food borne pathogens
- Factors controlling protein solubility and stability, especially in
diseases of aging
- Identifying motifs in and modeling of nucleases in DNA repair
- Cytokine interactions with ribonucleases in chronic diseases
- Production and mechanism of action of pharmaceutically interesting proteins
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