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Associate

Patricia Moussatche

Education

  • BA in Biology. Bard College, New York (1998)
  • PhD in Plant Molecular and Cellular Biology. University of Florida (2004)

Research summary

My current research focuses on understanding the pathway of nucleic acid incorporation into DNA. By using non-standard bases, we can dissect the pathway and identify essential enzymes. These non-standard bases can also be used to create a 6-base genetic code, if we can engineer the enzymes in the pathway to incorporate them into DNA.

Recent Publications

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Isothermal titration calorimetry uncovers substrate promiscuity of bicupin oxalate oxidase from Ceriporiopsis subvermispora
Rana H, Moussatche P, Rocha LS, Abdellaoui S, Minteer SD, Moomaw EW
Biochem. Biophys. Rep. , Elsevier (2016) 5:396-400 doi:10.1016/j.bbrep.2016.01.016
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Alternative Watson-Crick Synthetic Genetic Systems
Steven A. Benner, Nilesh B. Karalkar, Shuichi Hoshika, Roberto Laos, Ryan W. Shaw, Mariko Matsuura, Diego Fajardo, and Patricia Moussatche
Cold Spring Harb Perspect Biol , Cold Spring Harbor Laboratory Press (2016) doi: 10.1101/cshperspect.a023770
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A norovirus detection architecture based on isothermal amplification and expanded genetic systems
Ozlem Yaren, Kevin M. Bradley, Patricia Moussatche, Shuichi Hoshika, Zunyi Yang,Shu Zhu, Stephanie M. Karst, Steven A. Benner
J Virol Methods (237) , Elsevier 64-71 (2016) doi: 10.1016/j.jviromet.2016.08.012
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A Single Deoxynucleoside Kinase Variant from Drosophila melanogaster Synthesizes Monophosphates of Nucleosides That Are Components of an Expanded Genetic System
Mariko F. Matsuura, Christian B. Winiger, Ryan W. Shaw, Myong-Jung Kim, Myong-Sang Kim, Ashley B. Daugherty, Fei Chen, Patricia Moussatche, Jennifer D. Moses, Stefan Lutz, and Steven A. Benner
ACS Synthetic Biology , American Chemical Society (2016) DOI: 10.1021/acssynbio.6b00228
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Kinetic and Spectroscopic Studies of Bicupin Oxalate Oxidase and Putative Active Site Mutants
Moomaw EW, Hoffer E, Moussatche P, Salerno JC, Grant M, et al.
PLOS One , Public Library of Science (2013) 8(3): e57933
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Non-genomic progesterone signalling and its non-canonical receptor
Moussatche P, Lyons TJ
Biochem Soc Trans (2012) Feb;40(1):200-4
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Characterization of Ceriporiopsis subvermispora bicupin oxalate oxidase expressed in Pichia pastoris
Moussatche, P; Angerhofer, A; Imaram, W; Hoffer, E; Uberto, K; Brooks, C; Bruce, C; Sledge, D; Richards, NGJ; Moomaw, EW
Arch. Biochem. Biophys. (2011) May 1;509(1):100-7. Epub 2011 Mar 2
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Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets
Villa NY, Moussatche P, Chamberlin SG, Kumar A, Lyons TJ
J Mol Evol (2011) Oct;73(3-4):134-52. Epub 2011 Oct 19.
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Metal dependence of oxalate decarboxylase activity
Moomaw, EW; Angerhofer, A; Moussatche, P; Ozarowski, A; GarcĂ­a-Rubio, I; Richards, NG
Biochemistry 48 (26) 6116-6125 (2009)
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Crystallographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases
Berthold, CL; Toyota, CG; Moussatche, P; Wood, MD; Leeper, F; Richards, NGJ; Lindqvist, Y
Structure 15 (7) 853-861 (2007)
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